Pregnancy loss and thrombophilia: the elusive link
نویسندگان
چکیده
منابع مشابه
Recurrent Pregnancy Loss and Thrombophilia
In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication suc...
متن کاملThrombophilia and Recurrent Pregnancy Loss
Recurrent pregnancy loss (RPL) is usually defined as the loss of three or more consecutive pregnancies before 20 weeks of gestation. Within this definition is a large and heterogeneous group of patients with many different causes of miscarriage. RPL is a common clinical problem that occurs in approximately 1 % of reproductive-aged women. However, this frequency increases up to 5% when clinician...
متن کاملinherited thrombophilia and recurrent pregnancy loss
conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional acti...
متن کاملInherited Thrombophilia and Recurrent Pregnancy Loss
BACKGROUND Recurrent pregnancy loss (RPL) is a common health problem. The polymorphisms G20210A of prothrombin gene (FII G 20210A), and G 1691A of factor V gene (Factor V Leiden, FVL) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. OBJECTIVES To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S def...
متن کاملThrombophilia and pregnancy loss in first intended pregnancy.
Recurrent pregnancy loss is a common health problem affecting 1–5% of women at the reproductive age and bears significant emotional, social and economical impact [1]. A number of case–control and cohort studies have suggested an association between inherited thrombophilia and recurrent pregnancy loss while others refuted this occurrence [2–6]. Several recently reported meta-analysis support an ...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2012
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2012.09112.x